Putative cases where a substitution causes a switch to a binding site that is active in the same condition as the ��wild-type��.

Nine cases are described where two motifs, which are members of the filtered dataset, differ by one nucleotide from each other, and show significant coherence in a shared biological condition. The mean expression profiles of genes harboring these motifs in their promoters are different (Pearson correlation coefficient 0.05), implying that the substitution that would switch one motif to the other would cause a binding site switch.