Interstitial mycosis fungoides

ABSTRACT Interstitial mycosis fungoides (IMF) is a rare variant of mycosis fungoides, a cutaneous T-cell non-Hodgkin’s lymphoma. It is characterized by an interstitial dermal infiltrate of lymphocytes and histiocytes between collagen bundles. We report the case of a 54-year-old patient with pruritic hypochromic macules on the arms and forearms diagnosed with IMF. Special attention was given to the anatomopathological features that differentiate this entity from its differential diagnoses, such as inflammatory morphea, interstitial annular granuloma, and other variants of the mycosis fungoides itself. We also present a review of the literature on the classification of the IMF.

**摘要** 间质性蕈样肉芽肿（Interstitial mycosis fungoides, IMF）是蕈样肉芽肿的罕见亚型，而蕈样肉芽肿属于皮肤T细胞非霍奇金淋巴瘤。该病以胶原束间淋巴细胞与组织细胞形成的真皮间质浸润为特征。本文报告1例54岁患者，其手臂及前臂出现瘙痒性淡色斑疹，经诊断为IMF。本文重点阐述了可将该疾病与炎性硬斑病、间质性环状肉芽肿及蕈样肉芽肿其他亚型等鉴别诊断区分开的组织病理学特征，并对IMF分类相关的文献进行了综述。