Highly Enantio- and Diastereoselective Allylic Alkylation of Morita–Baylis–Hillman Carbonates with Allyl Ketones
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https://figshare.com/articles/dataset/Highly_Enantio_and_Diastereoselective_Allylic_Alkylation_of_Morita_Baylis_Hillman_Carbonates_with_Allyl_Ketones/2413933
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资源简介：
The asymmetric allylic alkylation
of Morita–Baylis–Hillman
(MBH) carbonates with allyl ketones has been developed. The α-regioselective
alkylation adducts, containing a hexa-1,5-diene framework with important
synthetic value, were achieved in up to 83% yield, >99% ee, and 50:1 dr by using a commercially available Cinchona alkaloid as the catalyst. From the allylic alkylation
adduct, a
cyclohexene bearing two adjacent chiral centers was readily prepared.
创建时间：
2016-02-19
