The Pediatric Template of Brain Perfusion (PTBP)

Magnetic resonance imaging (MRI) captures the dynamics of brain development with high spatial resolu- tion and with complementary modalities that quantify both brain structure and function. These measurements may yield valuable insights into the neural patterns that mark healthy maturation or that identify early risk for psychiatric disorder later in life. The Pediatric Template of Brain Perfusion (PTBP) is a free and public neuroimaging resource that will help accelerate the understanding of childhood brain development as seen through the lens of multiple modality neuroimaging and in relation to cognitive and environmental factors. The PTBP uses MRI to quantify cortex (T1), white matter (DTI), resting state functional connectivity (BOLD) and brain perfusion, as measured by Arterial Spin Labeling (ASL), in >100 children 7—17 years of age. The PTBP captures, within normally developing children and across several modalities, the trajectories that demarcate critical turning points in brain maturation. This novel resource allows a more detailed understanding of the structural and functional landmarks that are obtained during normal adolescent brain development. This is currently a pre-publication example of a single subject. The full raw nifti dataset is available at the link below. The PTBP was supported by Danny JJ Wang's R01MH080892磁共振成像（Magnetic resonance imaging, MRI）可凭借高空间分辨率捕捉脑发育的动态过程，并通过可同时量化脑结构与功能的互补成像模态获取多维度观测数据。此类测量结果可为揭示标志健康脑成熟进程的神经模式，或是识别个体日后罹患精神疾病早期风险的神经模式提供极具价值的研究见解。儿童脑灌注模板（Pediatric Template of Brain Perfusion, PTBP）是一款免费公开的神经影像资源，旨在通过多模态神经影像视角，并结合认知与环境相关因素，加速对儿童脑发育的研究认知。PTBP以7至17岁的100余名儿童为研究对象，借助磁共振成像量化其皮层（T1加权成像）、白质（弥散张量成像, DTI）、静息态功能连接（血氧水平依赖, BOLD），以及通过动脉自旋标记（Arterial Spin Labeling, ASL）测得的脑灌注水平。该模板覆盖了正常发育儿童群体中，多种模态下标志脑成熟关键转折点的发育轨迹。这款创新性资源可帮助研究者更细致地解析正常青少年脑发育过程中所观测到的结构与功能标志物。当前展示的仅为单例受试者的预发表示例。完整的原始NIfTI数据集可通过下方链接获取。本PTBP研究由Danny JJ Wang主持的R01MH080892项目资助。