Prefrontal-Subcortical Pathways Mediating Successful Emotion Regulation

A collection of 37 brain maps. Each brain map is a 3D array of values representing properties of the brain at different locations.

### Collection description

<p>OpenfMRI ds000108. Although prefrontal cortex has been implicated in the cognitive regulation of emotion, the cortical-subcortical interactions that mediate this ability remain poorly understood. To address this issue, we identified a right ventrolateral prefrontal region (vlPFC) whose activity correlated with reduced negative emotional experience during cognitive reappraisal of aversive images. We then applied a pathway-mapping analysis on subcortical regions to locate mediators of the association between vlPFC activity and reappraisal success (i.e., reductions in reported emotion). Results identified two separable pathways that together explained approximately 50% of the reported variance in self-reported emotion: (1) a path through nucleus accumbens that predicted greater reappraisal success, and (2) a path through ventral amygdala that predicted reduced reappraisal success (i.e., more negative emotion). These results provide direct evidence that vlPFC is involved in both the generation and regulation of emotion through different subcortical pathways, suggesting a general role for this region in appraisal processes.</p>

本数据集汇集了37张脑图谱。每张脑图谱均代表大脑在不同位置的属性，以三维数组的形式呈现。

### 数据集描述

<p>OpenfMRI ds000108。尽管前额叶皮层在情绪认知调节中已被涉及，但介导此能力的皮层-皮层下相互作用仍然理解不足。为解决这一问题，我们确定了一个右侧腹侧前额叶区域（vlPFC），其活动与认知重评厌恶图像时的负面情绪体验减少相关。随后，我们对皮层下区域进行了通路映射分析，以定位vlPFC活动与重评成功（即情绪报告减少）之间的关联的调节者。结果确定了两个可分离的通路，共同解释了情绪自我报告中约50%的变异：（1）通过伏隔核的通路预测了更高的重评成功；（2）通过腹侧杏仁核的通路预测了重评成功降低（即更负面的情绪）。这些结果直接证明vlPFC通过不同的皮层下通路参与了情绪的产生和调节，暗示该区域在评估过程中的普遍作用。</p>