Oral and anal microbiome from HIV-exposed individuals: role of host-associated factors in taxa composition and metabolic pathways.

Evidence indicates that the microbiome plays a significant role in HIV immunopathogenesis as well as in HIV-associated complications. In Argentina, men who have sex with men (MSM) and transgender women (TGW) are at the highest risk for infection with HIV and AIDS-related viruses. This study aimed to characterize the oral and anal microbiome of MSM and TGW with and without HIV. One hundred and thirty oral and anal DNA-derived samples were obtained from 78 participants and subjected to shotgun metagenomics sequencing for further microbiome analysis.