Structure based design of RIP1 kinase inhibitors
收藏Protein Data Bank Japan2024-03-13 更新2026-03-21 收录
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Structure based design of RIP1 kinase inhibitors Descriptor: (3S)-3-(2-benzyl-3-chloro-7-oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-8-carbonitrile, Receptor-interacting serine/threonine-protein kinase 1 Authors: Saikatendu, K.S, Yoshikawa, M. Deposit date: 2018-01-11 Release date: 2018-03-21 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.52 Å) Cite: Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. J. Med. Chem., 61, 2018
创建时间：
2018-01-11
