Wound healing mechanisms in pathogenesis control in natural SIV host species [rectal tissue]

We devised a systems biology approach to investigate the early host response to high-dose rectal SIV transmission, by transcriptomic comparative analysis of a natural reservoir host SIV model species, African green monkeys (AGMs – Chlorocebus sabaeus, N=28) and a pathogenic model, rhesus macaques (RMs - Macaca mulatta, N=24).on rectal tissues for both AGMs and RMs. Serial necropsies were performed at time points as early as one-day post-infection, and RNA-Seq was performed on rectal tissues for both AGMs and RMs.