Additional file 3 of Sequential drug treatment targeting cell cycle and cell fate regulatory programs blocks non-genetic cancer evolution in acute lymphoblastic leukemia

Additional file 3. Table S3 Summary of scRNAseq samples and cluster marker gene statistical analyses. Data filtering: scRNAseq sample filtering cutoffs and number of cells used in analysis. Differentially expressed genes from comparison of AZD1775-specific clusters (cell states 5-11) and DMSO cell state 4 (matching G2/M cell cycle phase) from 24 h time point in RS4;11 cells, heatmap cluster assignment (refer to Fig. S2e) and summary of pathway results. Marker gene lists for 24 h time point RS4;11 cell AZD1775-specific clusters. List of cell fate III top markers. In vivo samples: MLL-7 PDX AZD1775 treatment (28 h) cluster 6 marker genes and summary of pathway analysis; MLL-7 PDX AZD1775 treatment (day 6) corresponding pathway analysis for cells matched to 28 h cluster 6; RS4;11 in vivo marker genes for 11 clusters of data merged across treatments.