Single Nucleus RNA Sequencing of Pre-Malignant Liver Reveals Disease-Associated Hepatocyte State with HCC Prognostic Potential
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资源简介：
Expression profiling by high throughput sequencing.
To identify and characterize cell states associated with the chronically injured pre-malignant liver, we employed a droplet-based (10x chromium) single nucleus transcriptomics approach. Hepatic nuclei were isolated and profiled from (a) healthy mice fed normal chow, (b) mice subjected to a choline-deficient, ethionine-supplemented (CDE) diet, and (c) mice provided with thioacetamide (TAA) in the drinking water. We obtained a total of 40,748 single nucleus transcriptomes (16,222 healthy; 14,507 CDE; and 10,019 TAA) from three mice per condition.
提供机构：
The University of Western Australia
