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Therapeutic ablation of gain-of-function mutant p53 in colorectal cancer inhibits Stat3-mediated tumor growth and invasion

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NIAID Data Ecosystem2026-03-10 收录
下载链接:
https://www.ncbi.nlm.nih.gov/bioproject/PRJNA476326
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资源简介:
Panel NGS sequencing including TP53 from colon/rectal cancer patient using histological FFPE-DNA to identify missense p53 mutants which highly stabilize their p53 protein to increase Stat3 signaling. Result: CRC patients with stabilized missense p53 mutants exhibit enhanced Jak2/Stat3 signaling and poorer survival
创建时间:
2018-06-15
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