Organocatalyzed Multicomponent Synthesis of Isoxazolidin-5-ones
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https://figshare.com/articles/dataset/Organocatalyzed_Multicomponent_Synthesis_of_Isoxazolidin_5_ones/2112490
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资源简介：
An unprecedented multicomponent organocatalyzed
Knoevenagel–aza-Michael–cyclocondensation
reaction between Meldrum’s acid, hydroxylamines, and aldehydes
afforded a straightforward entry to a large array of racemic and syn-diastereoenriched isoxazolidinones as synthetically
useful scaffolds. This process revealed a markedly facile aza-Michael–cyclocondensation
sequence as a key domino reaction between RCO2NHOH and
transient alkylidene Meldrum’s acid upon Brønsted base
catalysis.
创建时间：
2016-02-12
