LncRNA Chaer contributes to the transcriptome reprogramming during phenylephrine-induced hypertrophy in neonatal rat ventricular myocytes

We compared the transcriptome modified by siRNA-mediated cardiac hypertrophy associated epigenentic regulator (Chaer) with negative control siRNA treated neonatal rat ventricular myocytes with or without phenylephrine treatment. The results suggest that Chaer knockdown broadly blocks the phenylephrine-induced hypertrophic programming of the transcriptome.我们将经小干扰RNA（siRNA）介导的心肌肥大相关表观遗传调控因子Chaer修饰后的转录组，与经阴性对照siRNA处理、且分别经或未经苯肾上腺素（phenylephrine）处理的新生大鼠心室肌细胞的转录组进行了比较。实验结果表明，Chaer敲低可广泛阻断苯肾上腺素诱导的转录组肥大程序。