Whole-genome-sequencing of triple negative breast cancers: a population study

Exploring the value of WGS in clinical setting, we sequenced 254 triple negative breast cancers (TNBC) with associated treatment and outcome data collected between 2010-2015 via the population-based Sweden Cancerome Analysis Network-Breast (SCAN-B) (ClinicalTrials.gov ID:NCT02306096) project. Somatic mutations (point mutations, small insertions and deletions, chromosomal rearrangements), as well as copy number profiles from whole genome sequences of triple negative breast cancers. Data for 237 samples included in the analysis as reported in the publication. The repository contains: - cohort summary: data frame summarising all the samples in the study, genomes and clinical data, and description of the columns - copy number: all copy number profiles from ASCAT - indels: single file with all passed Pindel indels, after filtering - rearrangements: filtered (simple filtered format) and unfiltered (bedpe) files - substitutions: single file with substitutions after filtering - Mapping of WGS sequencing IDs to RNAseq data for GSE96058