Calix[6]azacryptand Ligand with a Sterically Protected Tren-Based Coordination Site for Metal Ions

A new
calix[6]­azacryptand ligand has been prepared in six steps
starting from 1,3,5-trismethoxycalix[6]­arene. An X-ray study shows
that this ligand has a sterically protected tren-based binding site
at the bottom of a polyaromatic bowl and ether sites around its rim.
It binds Zn2+ to give a complex in which zinc is in a trigonal
bipyramidal geometry with a water bound in one apical position and
two additional hydrogen-bonded waters that fill the calixarene cavity.