Proteomic Analysis of Minimally Damaged Renal Tubular Tissue from Two-Kidney-One-Clip Hypertensive Rats Demonstrates Extensive Changes Compared to Tissue from Controls

Tubular atrophy and interstitial fibrosis present the final stage in most forms of progressive kidney diseases. Little is known regarding the early changes in the tubular proteome. In this study, we investigated changes in the tubular proteome of normal or near-normal tubular tissue in the non-clipped kidney from rats with two-kidney one-clip (2K1C) hypertension