Supplementary data Ettore Mosca, Matteo Bersanelli, Tommaso Matteuzzi, Noemi Di Nanni, Gastone Castellani, Luciano Milanesi, Daniel Remondini, Characterization and comparison of gene-centered human
Background: Complex biological networks control fundamental processes such as reproduction. The relationship of network structure to biological function was investigated in a global gene interaction n
We constructed a combinatorial CRISPR guide library to target ~200,000 pairwise combinations of 461 genes associated with DNA Repair. Overall design: eHAP-iCas9 cells harboring this library were grown
This network was assembled automatically by INDRA (http://indra.bio) by processing all available biomedical literature with multiple machine reading systems, and integrating curated pathway databases.