Visible-Light-Driven Difluoroacetamidation of Unactive Arenes and Heteroarenes by Direct C–H Functionalization at Room Temperature

The directed difluoro­acetamida­tion
of unactivated arenes
and heteroarenes with bromo­difluoro­acetamides via visible-light
photoredox catalysis has been efficiently achieved at room temperature.
Broad utility of this transformation is presented, including electronically
deficient heteroaromatic and aromatic systems. The mechanistic pathway
of the difluoro­acetamida­tion was discussed based on photoluminescence
quenching, spin-trapping, and kinetic isotope effect experiments.