Visible-Light-Driven Difluoroacetamidation of Unactive Arenes and Heteroarenes by Direct C–H Functionalization at Room Temperature

The directed difluoro­acetamida­tion of unactivated arenes and heteroarenes with bromo­difluoro­acetamides via visible-light photoredox catalysis has been efficiently achieved at room temperature. Broad utility of this transformation is presented, including electronically deficient heteroaromatic and aromatic systems. The mechanistic pathway of the difluoro­acetamida­tion was discussed based on photoluminescence quenching, spin-trapping, and kinetic isotope effect experiments.