EGFR Exon20 insertion mutant SVD bound with STX-721
收藏Protein Data Bank Japan2025-07-23 更新2026-04-19 收录
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EGFR Exon20 insertion mutant SVD bound with STX-721 Descriptor: (2P)-3-(3-chloro-2-methoxyanilino)-2-[3-({(2R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]-2-methylpyrrolidin-2-yl}ethynyl)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one, 1,2-ETHANEDIOL, CHLORIDE ION, ... Authors: Hilbert, B.J, Brooijmans, N, Pagliarini, R.A, Milgram, B.C. Deposit date: 2024-08-29 Release date: 2025-05-14 Last modified: 2025-07-23 Method: X-RAY DIFFRACTION (1.78 Å) Cite: STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20-Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models. Clin.Cancer Res., 31, 2025
创建时间：
2024-08-29
