Supplementary table III. Effectiveness of dupilumab, regression coefficients

Est., estimated; SE, standard error; EASI, Eczema Area and Severity Index; IGA, Investigator Global Assessment; NRS, Numerical Rating Scale; DLQI, Dermatology Life Quality Index; POEM, Patient-Oriented Eczema Measure; Estimated scores/changes are based on our linear mixed-effects models; Significant results are presented in bold face; a Threshold coefficients for IGA: 0|1 -8.5 (SE 1.1), 1|2 -5.5 (1.1), 2|3 -2.3 (1.1), 3|4 0.7 (1.1), threshold coefficients for NRS mean 7 days: 0|1 -6.7 (SE 1.1), 1|2 -4.9 (1.1), 2|3 -3.6 (1.1), 3|4 -2.5 (1.1), 4|5 -1.8 (1.1), 5|6 -1.1 (1.1), 6|7 -0.2 (1.1), 7|8 1.0 (1.1), 8|9 2.3 (1.1), 9|10 3.8 (1.1), threshold coefficients for NRS peak 24 hours: 0|1 -9.4 (SE 2.0), 1|2 -7.7 (2.0), 2|3 -6.5 (2.0), 3|4 -5.4 (2.0), 4|5 -4.7 (2.0), 5|6 -4.2 (2.0), 6|7 -3.3 (2.0), 7|8 -2.3 (2.0), 8|9 -0.91 (2.0), 9|10 0.96 (2.0); b Registered in the Amsterdam UMC only.