Crystal structure of CDK2-cyclin E1 bound by compound 11 (AZD8421)

Crystal structure of CDK2-cyclin E1 bound by compound 11 (AZD8421) Descriptor: (3~{S})-~{N}-ethyl-3-[[9-ethyl-2-[[(2~{R},3~{S})-2-oxidanylpentan-3-yl]amino]purin-6-yl]amino]pyrrolidine-1-sulfonamide, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1 Authors: Collie, G.W, Pflug, A. Deposit date: 2024-09-06 Release date: 2025-09-10 Last modified: 2025-09-24 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Discovery of AZD8421: A Potent CDK2 Inhibitor with Selectivity Against Other CDK Family Members and the Human Kinome. J.Med.Chem., 68, 2025