Impact of objective nutritional indexes on 1-year mortality after transcatheter aortic valve implantation: a prospective observational cohort study

The prognostic value of objective nutritional indexes has been demonstrated in many diseases. This study evaluated the prognostic value of these indexes in patients who underwent transcatheter aortic valve replacement (TAVI). Totally, 119 consecutive patients who underwent TAVI between January 2016 and December 2018 were evaluated. All patients were followed-up for one year. Objective nutritional index (geriatric nutritional risk index [GNRI], prognostic nutritional index [PNI]) and controlling nutritional status [CONUT]) scores were calculated before TAVI. Mean age of the study population was 77.1 ± 7.8 years (59.7% female). During one-year follow-up, 31 (26.1%) deaths were observed. In a Kaplan–Meier analysis, mortality rates were significantly increased in patients with lower GNRI and PNI and higher CONUT scores (50.01% vs. 4.4%; <i>p</i> p p p p The GNRI, PNI and CONUT scores were associated with 1-year all-cause mortality in patients who underwent TAVI. The predictive value of the GNRI score was significantly better than the PNI or CONUT scores. Assessment of the GNRI should be considered before TAVI.客观营养指标的预后价值已在多种疾病中得到证实。本研究评估了此类指标在接受经导管主动脉瓣置换术（TAVI）患者中的预后价值。最终纳入2016年1月至2018年12月期间接受TAVI的119例连续入组患者，所有患者均完成为期1年的随访。于术前计算患者的三项客观营养指标评分，包括老年营养风险指数（GNRI）、预后营养指数（PNI）及控制营养状况评分（CONUT）。本研究队列的平均年龄为77.1±7.8岁，女性占比59.7%。1年随访期间共观察到31例死亡事件，总体死亡率为26.1%。Kaplan-Meier分析显示，GNRI与PNI水平较低、CONUT评分较高的患者，其死亡率显著升高（50.01% vs 4.4%；*p* < 0.001）。GNRI、PNI及CONUT评分均与TAVI患者的1年全因死亡率相关；其中GNRI评分的预测价值显著优于PNI与CONUT评分。临床应考虑在TAVI术前对患者进行GNRI评估。