FluPRINT Study: Characterisation of the Immune and Transcriptional Response to LAIV

The development of universal influenza vaccines requires eliciting durable T stem cell-like memory (TSCM) responses, yet the baseline determinants governing TSCM expansion remain undefined. Here, using multi-omic systems immunology in a pediatric cohort immunized with live attenuated influenza vaccine (LAIV), we identify a pre-existing state of innate antiviral readiness as the master determinant of vaccine-mediated TSCM induction. This submission contains the baseline (Visit 1) whole-blood transcriptional profiles of 19 healthy children (ages 4-6) prior to vaccination. Overall design: Whole blood samples were collected from healthy children (4-6 years old) at baseline (Visit 1) prior to administration of the live attenuated influenza vaccine (LAIV). Total RNA was extracted and sequenced to identify pre-existing transcriptional signatures associated with subsequent vaccine responses.