Crystal structure of the yeast 20S proteasome in complex with Salinosporamide derivatives: slow substrate ligand
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Crystal structure of the yeast 20S proteasome in complex with Salinosporamide derivatives: slow substrate ligand Descriptor: (2R,3S,4R)-2-[(S)-(1S)-cyclohex-2-en-1-yl(hydroxy)methyl]-4-(2-fluoroethyl)-3-hydroxy-3-methyl-5-oxopyrrolidine-2-carbaldehyde, Proteasome component C1, Proteasome component C11, ... Authors: Groll, M, Macherla, V.R, Manam, R.R, Arthur, K.A.M, Potts, C.B. Deposit date: 2009-03-23 Release date: 2009-09-15 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition J.Med.Chem., 52, 2009
创建时间：
2009-03-23
