Asymmetric Palladium-Catalyzed C–H Functionalization Cascade for Synthesis of Chiral 3,4-Dihydroisoquinolones
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下载链接：
https://figshare.com/articles/dataset/Asymmetric_Palladium-Catalyzed_C_H_Functionalization_Cascade_for_Synthesis_of_Chiral_3_4-Dihydroisoquinolones/9788405
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资源简介：
A palladium-catalyzed C–H
functionalization/intramolecular
asymmetric allylation cascade of N-sulfonyl benzamides
with 1,3-dienes has been developed. In the presence of a chiral pyridine–oxazoline
ligand, this protocol enables the synthesis of chiral 3,4-dihydroisoquinolones
in yields of up to 83% with enantioselectivities of up to 96%, using
environmentally friendly air as the terminal oxidant.
创建时间：
2019-09-02
