CGH analysis of Candida albicans strains. Candida albicans

Aneuploidy and the evolution of aneuploid karyotypes of Candida albicans strains was identified using aCGH. Whole chromosome and segmental aneuploidies, (specifically on the left arm of chromosome 5 - shown to be due to isochromosome formation) are associated with the appearance of resistance to the antifungal drug fluconazole. Keywords: Comparative Genomic Hybridization Overall design: Hybridization of all strains was compared to the hybridization of SC5314, the sequenced laboratory strain.