Fear conditioning biases olfactory sensory neuron frequencies across generations

We investigated changes in the cellular composition of the olfactory epithelium in response to an aversive stimulus. Using intact, optically cleared main olfactory epithelia from mice that underwent olfactory fear conditioning, we developed a dataset demonstrating that olfactory fear conditioning increases the number of odor-encoding neurons in mice that experience odor-shock conditioning (F0), as well as in their unconditioned offspring (F1). We provide evidence that the increase in F0 is due, in part, to the biasing of the stem cell layer of the main olfactory epithelium. A robust dataset of F1 behavioral metrics revealed subtle odor-specific differences between the offspring of unconditioned and conditioned parents, despite the absence of an active aversion to the conditioned odor.
, , # Fear conditioning biases olfactory sensory neuron frequencies across generations 

Dataset DOI: [10.5061/dryad.80gb5mm4m](https://doi.org/10.5061/dryad.80gb5mm4m)

## Description of the data and file structure

There is a CSV file containing the raw data for every data-containing subfigure in the manuscript, along with a \"subject_details\" CSV file containing details for every animal used to generate that data. Data files are terminated with \"data.csv,\" while subject details files are terminated with \"subject_details.csv.\" The number indicates the associated figure number in the manuscript, while the letter indicates the subfigure. For example, \"1A_data.csv\" would refer to the data file for Figure 1A. For prefixes containing an \"S,\" the first number refers to the main figure to which the figure supplement is attached, and the second number refers to the figure supplement number. For example, \"1S1\" refers to Figure 1-Figure supplement 1.

### Files and variables

#### File: Dryad_Submis..., ,