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Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical isolate PR20 with the potent antiviral inhibitor GRL-0519A

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Protein Data Bank Japan2023-09-20 更新2026-03-21 收录
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https://pdbj.org/mine/summary/4j54
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Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical isolate PR20 with the potent antiviral inhibitor GRL-0519A Descriptor: (3R,3aS,3bR,6aS,7aS)-octahydrodifuro[2,3-b:3',2'-d]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}propyl]carbamate, ACETATE ION, IODIDE ION, ... Authors: Wang, Y.-F, Agniswamy, J, Weber, I.T. Deposit date: 2013-02-07 Release date: 2013-05-15 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Extreme Multidrug Resistant HIV-1 Protease with 20 Mutations Is Resistant to Novel Protease Inhibitors with P1'-Pyrrolidinone or P2-Tris-tetrahydrofuran. J.Med.Chem., 56, 2013
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2013-02-07
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