Supplementary Material for: Statin Intake and All-Cause Mortality among Older Nursing Home Residents

<b><i>Background:</i></b> Statins are progressively accepted as being associated with reduced mortality. However, few real-world statin studies have been conducted on statin use in older people and especially the most frail, that is, the nursing home residents. <b><i>Objective:</i></b> The aim of this study was to evaluate the impact of statin intake in nursing home residents on all-cause mortality. <b><i>Method:</i></b> This is a cross-sectional study of 1,094 older people residing in 6 nursing homes in Flanders (Belgium) between March 1, 2020 and May 30, 2020. We considered all residents who were taking statins for at least 5 days as statin users. All-cause mortality during the 3 months of data collection was the primary outcome. Propensity score overlap-weighted logistic regression models were applied with age, sex, functional status, diabetes, and cardiac failure/ischemia as potential confounders. <b><i>Results:</i></b> 185 out of 1,094 residents were on statin therapy (17%). The statin intake was associated with decreased all-cause mortality: 4% absolute risk reduction; adjusted odds ratio 0.50; CI 0.31–0.81, <i>p</i> = 0.005. <b><i>Conclusions:</i></b> The statin intake was associated with decreased all-cause mortality in older people residing in nursing homes. More in-depth studies investigating the potential geroprotector effect of statins in this population are needed.<b><i>研究背景：</i></b> 越来越多的临床证据表明他汀类药物（statins）可降低死亡率。然而，目前针对老年人群，尤其是身体最为虚弱的养老院居民的他汀类药物使用相关真实世界研究仍较为匮乏。<b><i>研究目的：</i></b> 本研究旨在评估养老院居民服用他汀类药物对全因死亡率的影响。<b><i>研究方法：</i></b> 本研究为横断面研究，纳入2020年3月1日至2020年5月30日期间居住在比利时佛兰德斯地区6所养老院的1094名老年人。我们将至少连续服用他汀类药物5天的居民定义为他汀类药物使用者。本研究的主要结局指标为数据收集周期内（3个月）的全因死亡率。本研究采用倾向得分重叠加权logistic回归模型，以年龄、性别、功能状态、糖尿病及心力衰竭/缺血作为潜在混杂因素进行校正。<b><i>研究结果：</i></b> 1094名研究对象中共有185人接受他汀类药物治疗，占比17%。服用他汀类药物与全因死亡率降低显著相关：绝对风险降低4%；校正后比值比为0.50，置信区间（Confidence Interval, CI）为0.31~0.81，p=0.005。<b><i>研究结论：</i></b> 本研究结果显示，养老院居住的老年人服用他汀类药物与全因死亡率降低相关。未来仍需开展更为深入的研究，以探讨他汀类药物在该人群中潜在的老年保护作用。