RNA sequencing of circular RNAs, long non-coding RNAs ,and mRNAs in human keloid dermal tissues

Keloid is a dermal fibroproliferative disease with various etiologies and unclear pathogenesis. Recent studies have revealed that circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs) exerted regulatory functions through a competing endogenous RNA (ceRNA) pathway in keloid progression. However, the expression profiles of circRNAs and lncRNAs in keloid dermal tissues (KDTs) remain unknown. This study aimed to identify differentially expressed circRNAs, lncRNAs and genes in KDTs. Overall design: Examination of RNA sequencing comparing the center of the keloid dermal tissue [C,n=4], the margin of the keloid dermal tissue [M,n=3], and normal skin from the same patients [N,n=4].