Vascular tumor spectrum in aP2-Cre mice

The combined activation of KrasG12D and loss of Cdkn2a leads to aggressive angiosarcomas in aP2-Cre mice. Whereas, the conditional deletion of Tsc1 leads to vascular tumor formation that mimic human kaposiform hemangioendotheliomas. We used Affymetrix microarrays to compare angiosarcoma tumors with the combined activation of KrasG12D and loss of Cdkn2a and the conditional deletion of Tsc1 Comparison of angiosarcoma tumors from aP2-Cre;LSL-KrasG12D;Cdkn2aFl/Fl (AKC mice) and tumors from aP2-Cre;Tsc1Fl/Fl mice (AT mice).