AcK-NFE2L2 binds the ABCG2 gene
收藏reactome.org2025-03-23 收录
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A detailed promoter analysis using luciferase reporter assays showed that ARE at -431 to -420 bp is critical for the NFE2L2-mediated expression in lung cancer cells. Electrophoretic mobility shift assays and chromatin immunoprecipitation assays revealed that NFE2L2 interacts with the ABCG2 ARE element at -431 to -420 bp in vitro and in vivo (Singh et al, 2010)<br>
通过对启动子进行深入分析,并采用荧光素酶报告基因实验,研究发现位于-431至-420碱基对的ARE元件对于NFE2L2介导的肺癌细胞表达至关重要。电泳迁移率变动实验和染色质免疫沉淀实验进一步揭示了NFE2L2在体外和体内与位于-431至-420碱基对的ABCG2 ARE元件发生相互作用(Singh等,2010年)
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