Transcriptomes across seven brain regions from mouse model of anxiety. Transcriptomes across seven brain regions from mouse model of anxiety

Anxiety disorders are highly heterogeneous diseases. The molecular mechanisms underlying multi-brain region origin and sex dimorphism remain largely unknown. Herein, by leveraging large-scale transcriptomes across seven brain regions from mouse model of anxiety and extensive experiments at the molecular, synapse activity, and behavior levels, we dissected brain region- and sex-specific gene networks and identified critical sex-specific mediators of anxiety susceptibility. Overall design: Total RNA of mouse brain were sequenced by deep sequencing using Illumina HiSeq 2500