Blending polysaccharides from three edible mushrooms (Pleurotus eryngii, Agrocybe aegerita, and Agaricus bisporus) represents a promising approach for augmenting their anti-oxidant and anti-fatigue activities

It has been well documented that a number of polysaccharides with robust free-radical scavenging capability possess notable anti-fatigue activity. Interestingly, recent evidence also suggested mixed polysaccharides derived from multiple sources may yield augmented bioactivities compared to the polysaccharides from a single source. Therefore, in the current study, we investigated the anti-oxidant and anti-fatigue activities of a blend of polysaccharides isolated from three mushrooms. These findings highlighted the potential application of blending polysaccharides from multiple mushroom sources in mitigating fatigue.