Values obtained from the steady-state inactivation protocol, and the calculated biophysical properties.
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Measurements with different drug concentrations (e.g. amitryptiline and riluzole) resulted in similar Kr and Ki values, which confirmed the reliability of the calculations. The table shows geometric mean of individual Kr, Ki−ΔV1/2 and Ki−Kapp data (arithmetic mean ± SEM values are shown in Results S7). Kr and Ki data from the literature were calculated and averaged as described in [19]. Averaged data are shown in columns Kr−Lit and Ki−Lit, except for trazodone [42] and flunarizine [43].
Abbr.:
aconcentration,
binhibition (inhibited fraction) at holding potential −150 mV,
cstate-dependence.
创建时间：
2010-12-20
