Genotype counts and statistics of association at rs16969681, rs11632715, and rs4779584.

All data sets in which rs16969681 and/or rs11632715 were genotyped are shown. The sample sets genotyped for the SNPs near GREM1 are overlapping, but non-identical, largely because rs11632715 and rs4779584 (but not rs16969681) are present on the proprietary Illumina genome-wide arrays, and also because the Cambridge data set was additionally genotyped for rs16969681. In addition to the overall association test statistics, the P value for the replication phase (excluding UK2 and Scotland2) is shown for rs16969681 and rs11632715. Although there is considerable overlap, the sample sets genotyped here differ somewhat from those typed for the BMP2 and BMP4 SNPs. These differences result entirely from sample and data availability and practical issues of genotyping, including the following: GWAS data but not samples were available from some data sets, so that SNPs such as rs16969681 could not be genotyped in those sample sets; the 1958 Birth Cohort samples were not available at the time of genotyping rs16969681; and for some sample sets, DNA quantity was limiting.