Efficacy of benznidazole (Bz) and itraconazole (Itz) treatments for 20 days (monotherapy or combination) in murine model of acute Trypanosoma cruzi infection.

1 Swiss female weight 18 to 22g were inoculated with 5x103 trypomastigotes (Y strain), treatment was initiated at 4 days after inoculation followed by 20 days and it was administered per oral route.2 Mean of doses (or days of treatment) required to induce the parasitemia supression.3 Fresh blood examination (FBE) before and after cyclophosphamide immunosuppression and PCR assays performed at 1st and 6th month post-treatment.Efficacy of benznidazole (Bz) and itraconazole (Itz) treatments for 20 days (monotherapy or combination) in murine model of acute Trypanosoma cruzi infection.