Lactoferrin attenuated deoxynivalenol induced malfunction in mouse testis

DON impaired the male spermatogenesis and induced oxidative stress, testicular apoptosis and disruption of blood-testis barrier (BTB). The milk protein lactoferrin (LF) is an iron-binding glycogenprotein with multifunctions including anti-inflammation and antioxidant. The current study was aimed to investigate the beneficial effects of LF on spermatogenesis and integray of BTB of mice treated with diet DON. Sexually mature male mice were fed diet inclusion of DON,and oral administration of LF for 35 days, a 2×2 factorial arrangement.