Concordance of the HumanMethylation 450K (450K) and MeDIP-seq (MD-s) data with bisulfite sequencing (BS-s) data using an interval-based approach.

The methylation levels for each individual CpG site assayed by the bisulfite data (BS-s) were classified as low, medium or high based on the output from MethTools. The boundaries for low, medium and high methylation intervals for each probe for the HumanMethylation 450K array (450K) and corresponding window for the MEDIPS data were determined by comparison to the bisulfite sequencing data. In the top part of the table the concordance between these intervals was calculated for all overlapping loci from the different methods for the regions covered by the bisulfite data. The second half of the table contains the concordance for a similar analysis for all autosomal chromosomes for the MeDIP-seq (MD-s) and HumanMethylation 450K data.