File S1 - Modulatory Effects of the Piccolo Genotype on Emotional Memory in Health and Depression

Figure S1: Flowchart of participants included in this study. NESDA: Netherlands Study of Depression and Anxiety; PCLO+: PCLO risk allele carriers; PCLO−: PCLO non-risk allele carriers; n: number of participants. Table S2: Optimal threshold calculation for multiple comparison correction. Table S3: Main effect of encoding and recognition, specified per valence. Table S4: PCLO genotype effect during task. Figure S5: Parameter estimates of correctly recognized old versus new words. Effect is shown at the amygdala (MNI [−27 −3 −24]: during rejection of positive new words, healthy PCLO− carriers showed increased left amygdalar activation, while no difference between processing positive old and new words was observed in PCLO+ carriers and in MDD patients, indicating blunting to novel positive information in PCLO+ carriers and patients. PCLO: Piccolo genotype; PCLO+: PCLO risk allele carriers; PCLO−: PCLO non-risk allele carriers; MDD: Major Depressive Disorder; HC: Healthy controls; AU: arbitrary units. (DOC)