Crystal structure of the human Kelch domain of Keap1 in complex with compound S217879
收藏Protein Data Bank Japan2024-05-01 更新2026-04-19 收录
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Crystal structure of the human Kelch domain of Keap1 in complex with compound S217879 Descriptor: 2-[(1S,2R,8S)-2,4,32-trimethyl-28,28-bis(oxidanylidene)-19,22,27-trioxa-28$l^{6}-thia-1,14,15,16-tetrazahexacyclo[21.5.3.1^{3,7}.1^{9,13}.0^{12,16}.0^{26,30}]tritriaconta-3(33),4,6,9(32),10,12,14,23,25,30-decaen-8-yl]ethanoic acid, Kelch-like ECH-associated protein 1 Authors: Weber, C, Vuillard, L, Delerive, P, Miallau, L. Deposit date: 2022-06-10 Release date: 2022-07-13 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.323 Å) Cite: Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice. JHEP Rep, 5, 2023
创建时间：
2022-06-10
