Genetic data-Dongxiang.xlsx

In comparison with the most
preferred genetic marker utilized in forensic science (STR), insertion/deletion
analysis possesses further benefits, like absence of stutter peak, low mutation
rate and enabling mixed stain analysis. At present, a total of 169 unrelated
healthy Dongxiang individuals dwelling in Dongxiang Autonomous county of Gansu
province were recruited in our study to appraise the forensic usefulness of the
panel including 30 autosomal diallelic genetic markers. The insertion allele
frequencies were in the range of 0.1598 at HLD 111 to 0.8850 at HLD 118. The
cumulative match of probability and the combined probability of exclusion were
estimated based on independence of pairwise loci, with the values of 3.96×10-11
and 0.9886, respectively, which showed tremendous potential of this panel to be
qualified for forensic personal identification in Chinese Dongxiang group. And
it could also be used as a complementary tool for forensic parentage testing
when combined with standard STR genetic markers. Furthermore, calculation of the
DA distance and Fst values of pairwise
populations, phylogenetic reconstruction, multidimensional scaling analysis,
structure clustering analysis were also conducted to probe the genetic
relationships between Dongxiang group and the other 30 reference populations. Results
demonstrated that Dongxiang ethnic group might be genetically closer related
with most Chinese populations involved in our study, especially Tibet groups,
Xibe group and several Han populations.