ZSCAN4 functions as a safeguard to maintain centromere integrity during oocyte meiosis

Figure 1. ZSCAN4 is a centromeric protein related to the proper maturation of mouse oocytes.
Figure 2. ZSCAN4 depletion causes centromere stretching due to microtubule pulling forces.
Figure 3. ZSCAN4 depletion impairs the recruitment of CENP-A, HEC1, and BubR1 at centromeres and kinetochores.
Figure 4. ZSCAN4 depletion disrupts pericentric heterochromatin assembly and chromosome architecture.
Figure 5. ZSCAN4 is essential for maintaining centromere integrity during prophase I arrest.
Figure 6. ZSCAN4 depletion impairs DNA repair by disrupting chromosomal relocation of the CIP2A-MDC1-TOPBP1 complex.