Expression data from mouse Malignant Mesothelioma (MM) tumors and normal tissues

With the goal of designing a universal vaccine that can be used to target MM in mice, we analyzed expression of all the mRNA produced by different MM tumors and normal tissues. Our hypothesis was that antigens highly expressed in MM tumors can be used as target for vaccination, as long the expression of those antigens is extremely low in all normal mouse tissues. mRNA was analyzed in two tumors originated from two different MM cell lines injected in BALB/c mice, CRH5 and EOH6. These cells were previously generated by injecting asbestos or erionite in the same strain of mice. For the normal tissues, we have analyzed antigen expression in lungs and kidneys isolated from naïve BALB/c mice.