Supplementary Table S1 from Pharmacological Inhibition of Centrosome Clustering by Slingshot-Mediated Cofilin Activation and Actin Cortex Destabilization

Screen result. For each library and concentration, compounds are divided into two groups, according to readout significance (black, P < 0.05; grey P > 0.05) and sorted from highest to lowest CCI index. Compounds highlighted in bold represent a CCI index higher than 0.3, indicating that viability of cells with CA was significantly affected in comparison to cells with normal centrosome content (by approx. 20%). Relative overall viability of each drug-treated cell population in comparison to the corresponding DMSO-treated population (maximum viability = 1) is indicated by rel.Control or rel.Tet. Compounds that eradicated both cell populations, giving a false positive result are highlighted in red (i.e. Crizotinib).