miR-146a is overexpressed and contributes to dampen IL-6 production in cystic fibrosis macrophages

In this study, we investigated whether miRNA deregulation might underlie the functional abnormalities of cystic fibrosis (CF) macrophages. To this aim we performed miRNA profiling in macrophages from CF and non-CF macrophages. This led to the identification of a panel of differentially expressed miRNAs in CF macrophages compared to non-CF cells. miRNA profiles of monocyte derived macrophages from six CF and six non-CF individuals were generated by microRNA-Seq.