Amino Acid Knowledgebase of CCR5

Amino Acid Matrix tab contains all compiled data for each amino acid of the human CCR5 sequence. Alignment matrix contains the 98 species sequences for CCR5 ortholog alignment. Paralog alignment contains all data for the 100 BLAST hits relative to human CCR5. Compiled variants contains the list of all extracted variants for CCR5 from gnomAD, TOPmed, COSMIC, ClinVar, and Geno2MP. Top 5 Geno2MP tab contains the phenotypes associated with the top 5 Geno2MP scoring variants for CCR5. md_analysis tab contains the mds analysis for movement and energy of human CCR5 protein over 300 nanoseconds. mds_analysisres contains the per amino acid movement and secondary structure annotations over the entire mds. mds_DCCM contains the correlation matrix for each amino acid to every other amino acid within the CCR5 protein structure.

氨基酸矩阵（Amino Acid Matrix）标签页收录人类CC趋化因子受体5（CCR5）序列各氨基酸的全部汇编数据。比对矩阵（Alignment Matrix）标签页包含用于CCR5直系同源比对的98个物种的序列数据集。旁系同源比对（Paralog Alignment）标签页包含针对人类CCR5的100条BLAST命中序列的完整数据。汇编变异集（Compiled Variants）标签页收录了从gnomAD、TOPmed、COSMIC、ClinVar及Geno2MP数据库中提取的全部CCR5相关变异列表。Top 5 Geno2MP标签页包含CCR5中Geno2MP评分排名前五的变异所关联的表型信息。md_analysis标签页包含人类CCR5蛋白在300纳秒时长内的运动与能量分子动力学模拟（MDS）分析数据。mds_analysisres标签页涵盖全MDS分析范围内的单氨基酸运动情况及二级结构注释数据。mds_DCCM标签页包含CCR5蛋白结构内各氨基酸与其余所有氨基酸之间的相关矩阵。