Polyfunctional Tetrahydropyrido[2,3-<i>b</i>]pyrazine Scaffolds from 4-Phenylsulfonyl Tetrafluoropyridine
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Polyfunctional tetrahydropyrido[2,3-b]pyrazine scaffolds can be synthesized by sequential reaction of pentafluoropyridine with sodium phenylsulfinate and an appropriate diamine. The polyfunctionality possessed by the difluorinated tetrahydropyrido[2,3-b]pyrazine scaffolds was demonstrated in selected model reactions with nucleophiles to give access to various polysubstituted [6,6]-ring fused systems.
创建时间:
2005-11-11



