Blood Count on Chow and High-Cholesterol Diet.

Blood count on chow (CD) and high-cholesterol diet (HCD). Whole blood samples of all three genotypes were taken from age-matched mice after 4 weeks of CD or HCD. Differential blood counts were obtained using an automated blood counter. Ldlr−/−;Rag-2−/− and Socs-1−/−triple-KO mice (Socs-1−/−) showed a significant leucopenia after correction for granulocytes compared to Ldlr−/− mice on CD and HCD. Leucopenia in Socs-1−/− triple-KO mice was compensated by a significant granulocytosis under both conditions compared to Ldlr−/− mice. Granulocytes mainly consisted of neutrophils. Data represent median with 25th and 75th percentiles, #p<0.05 vs Ldlr−/− and Socs-1−/− triple-KO mice, *p<0.05 vs Ldlr−/− mice, N = 13–21 mice/group.